Players — I
- Frank Duncan III 1941–1945
- Chris Iannetta 2006–2019
- Andy Ibanez 2021–2025
- Raul Ibanez 1996–2014
- Edgar Ibarra 2015–2015
- Ham Iburg 1902–1902
- Ryota Igarashi 2010–2012
- Kei Igawa 2007–2008
- Jose Iglesias 2011–2025
- Raisel Iglesias 2015–2025
- Gary Ignasiak 1973–1973
- Mike Ignasiak 1991–1995
- Tadahito Iguchi 2005–2008
- Blaise Ilsley 1994–1994
- Shota Imanaga 2024–2025
- Harry Imlay 1913–1913
- Pete Incaviglia 1986–1998
- Ender Inciarte 2014–2022
- Jonathan India 2021–2025
- Alexis Infante 1987–1990
- Greg Infante 2010–2018
- Omar Infante 2002–2016
- Brandon Inge 2001–2013
- Bob Ingersoll 1914–1914
- inger01 1905–1905
- Scotty Ingerton 1911–1911
- Joe Inglett 2006–2011
- Charlie Ingraham 1883–1883
- Garey Ingram 1994–1997
- Kolton Ingram 2023–2023
- Mel Ingram 1929–1929
- Riccardo Ingram 1994–1995
- Bert Inks 1891–1896
- Jeff Innis 1987–1993
- Dane Iorg 1977–1986
- Garth Iorg 1978–1987
- Happy Iott 1903–1903
- Hooks Iott 1941–1947
- Hideki Irabu 1997–2002
- Hal Irelan 1914–1914
- Tim Ireland 1981–1982
- Jairo Iriarte 2024–2024
- Hernan Iribarren 2008–2016
- Cal Irvin 1946–1947
- Cole Irvin 2019–2024
- Jake Irvin 2023–2025
- Monte Irvin 1938–1956
- Daryl Irvine 1990–1992
- Alex Irwin 1906–1906
- Arthur Irwin 1880–1894
- Bill Irwin 1886–1886
- Charlie Irwin 1893–1902
- Ed Irwin 1912–1912
- John Irwin 1882–1891
- Phil Irwin 2013–2014
- Tommy Irwin 1938–1938
- Walt Irwin 1921–1921
- irwin01 1937–1937
- Orlando Isales 1980–1980
- Kyle Isbel 2021–2025
- Frank Isbell 1898–1909
- Kazuhisa Ishii 2002–2005
- Travis Ishikawa 2006–2015
- Clarence Isreal 1940–1947
- Jason Isringhausen 1995–2012
- Tyler Ivey 2021–2021
- Mike Ivie 1971–1983
- K. B. Ivory 1936–1937
- Hisashi Iwakuma 2012–2017
- Akinori Iwamura 2007–2010
- Hank Izquierdo 1967–1967
- Hansel Izquierdo 2002–2002
- Cesar Izturis 2001–2013
- Maicer Izturis 2004–2014