Players — Z
- Ike Van Zandt 1901–1905
- Dick Van Zant 1888–1888
- Adrian Zabala 1945–1949
- Aneurys Zabala 2022–2022
- Zip Zabel 1913–1915
- Albert Zachary 1944–1944
- Chris Zachary 1963–1973
- Tom Zachary 1918–1936
- Elmer Zacher 1910–1910
- Pat Zachry 1976–1985
- George Zackert 1911–1912
- Mark Zagunis 2017–2019
- Mike Zagurski 2007–2018
- Geoff Zahn 1973–1985
- Fred Zahner 1894–1895
- Paul Zahniser 1923–1929
- Frankie Zak 1944–1946
- Jack Zalusky 1903–1903
- Carlos Zambrano 2001–2012
- Eddie Zambrano 1993–1994
- Victor Zambrano 2001–2007
- Carl Zamloch 1913–1913
- Daniel Zamora 2018–2021
- Oscar Zamora 1974–1978
- Dom Zanni 1958–1966
- Jim Zapp 1945–1948
- Joe Zapustas 1933–1933
- Mauro Zarate 2007–2007
- Jose Zardon 1945–1945
- Al Zarilla 1943–1953
- Jeff Zaske 1984–1984
- Rob Zastryzny 2016–2025
- Norm Zauchin 1951–1959
- Gregg Zaun 1995–2010
- Clay Zavada 2009–2009
- Seby Zavala 2019–2024
- Clint Zavaras 1989–1989
- Lance Zawadzki 2010–2010
- William Zay 1886–1886
- Joe Zdeb 1977–1979
- Dave Zearfoss 1896–1905
- George Zeber 1977–1978
- Ryan Zeferjahn 2024–2025
- Josh Zeid 2013–2014
- Rollie Zeider 1910–1918
- Henry Zeiher 1886–1886
- Todd Zeile 1989–2004
- Bart Zeller 1970–1970
- Bill Zepp 1969–1971
- Chad Zerbe 2000–2003
- Gus Zernial 1949–1959
- Angel Zerpa 2021–2025
- George Zettlein 1871–1876
- T. J. Zeuch 2019–2022
- Bob Zick 1954–1954
- Brad Ziegler 2008–2018
- Charlie Ziegler 1899–1900
- George Ziegler 1890–1890
- Steve Ziem 1987–1987
- Benny Zientara 1941–1948
- Bill Zies 1891–1891
- Matt Zieser 1914–1914
- Bradley Zimmer 2017–2022
- Charles Zimmer 1884–1903
- Don Zimmer 1954–1965
- Kyle Zimmer 2019–2021
- Bill Zimmerman 1915–1915
- Eddie Zimmerman 1906–1911
- Heinie Zimmerman 1907–1919
- Jeff Zimmerman 1999–2001
- Jerry Zimmerman 1961–1968
- Jordan Zimmerman 1999–1999
- Roy Zimmerman 1945–1945
- Ryan Zimmerman 2005–2021
- Bruce Zimmermann 2020–2025
- Jordan Zimmermann 2009–2021
- Charlie Zink 2008–2008
- Walter Zink 1921–1921
- Frank Zinn 1888–1888
- Guy Zinn 1911–1915
- Jimmy Zinn 1919–1929
- Bill Zinser 1944–1944
- Alan Zinter 2002–2004
- Bud Zipfel 1961–1962
- Richie Zisk 1971–1983
- Barry Zito 2000–2015
- Billy Zitzmann 1919–1929
- Ed Zmich 1910–1911
- Ben Zobrist 2006–2019
- Peter Zoccolillo 2003–2003
- Sam Zoldak 1944–1952
- Charles Zomphier 1926–1931
- Eddie Zosky 1991–2000
- Bill Zuber 1936–1947
- Jon Zuber 1996–1998
- Tyler Zuber 2020–2025
- Julio Zuleta 2000–2001
- Yosver Zulueta 2024–2025
- Joel Zumaya 2006–2010
- Mike Zunino 2013–2023
- Bob Zupcic 1991–1994
- Frank Zupo 1957–1961
- Paul Zuvella 1982–1991
- George Zuverink 1951–1959
- Guillermo Zuñiga 2023–2024
- Dutch Zwilling 1910–1916
- Tony Zych 2015–2017