Players — S
- Abel De Los Santos 2015–2016
- Enyel De Los Santos 2018–2025
- Fautino De Los Santos 2011–2012
- Luis De Los Santos 2024–2024
- Valerio De Los Santos 1998–2008
- Yerry De Los Santos 2022–2025
- Garton Del Savio 1943–1943
- Joe La Sorsa 2023–2025
- Tommy La Stella 2014–2023
- Andrew Saalfrank 2023–2025
- Kirk Saarloos 2002–2008
- CC Sabathia 2001–2019
- Erik Sabel 1999–2002
- Bret Saberhagen 1984–2001
- Alex Sabo 1936–1937
- Chris Sabo 1988–1996
- Blake Sabol 2023–2025
- Erik Sabrowski 2024–2025
- Mark Saccomanno 2008–2008
- Frank Sacka 1951–1953
- Brian Sackinsky 1996–1996
- Ray Sadecki 1960–1977
- Mike Sadek 1973–1981
- Bill Sadler 1935–1938
- Billy Sadler 2006–2009
- Carl Sadler 2002–2003
- Casey Sadler 2014–2021
- Donnie Sadler 1998–2007
- Ray Sadler 2005–2005
- Bob Sadowski 1960–1963
- Bob Sadowski 1963–1966
- Ed Sadowski 1960–1966
- Jim Sadowski 1974–1974
- Ryan Sadowski 2009–2009
- Ted Sadowski 1960–1962
- Connor Sadzeck 2018–2022
- Chris Saenz 2004–2004
- Olmedo Saenz 1994–2007
- Tom Saffell 1949–1955
- Harry Sage 1890–1890
- A. J. Sager 1994–1998
- Pony Sager 1871–1871
- Thomas Saggese 2024–2025
- Marc Sagmoen 1997–1997
- Vic Saier 1911–1919
- Johnny Sain 1942–1955
- Mike Saipe 1998–1998
- Takashi Saito 2006–2012
- Lenn Sakata 1977–1987
- Tyler Saladino 2015–2019
- Fernando Salas 2010–2019
- Juan Salas 2006–2008
- Marino Salas 2008–2008
- Mark Salas 1984–1991
- Wilfredo Salas 1948–1948
- Angel Salazar 1983–1988
- Cándido Salazar 1924–1924
- César Salazar 2023–2025
- Danny Salazar 2013–2019
- Eduardo Salazar 2023–2025
- Jeff Salazar 2006–2009
- Luis Salazar 1980–1992
- Lázaro Salazar 1930–1936
- Oscar Salazar 2002–2010
- Santiago Salazar 1945–1945
- Chris Sale 2010–2025
- Freddy Sale 1924–1924
- Ed Sales 1890–1890
- Harry Salisbury 1879–1882
- Solly Salisbury 1902–1902
- Bill Salkeld 1945–1950
- Roger Salkeld 1993–1996
- Slim Sallee 1908–1921
- Brad Salmon 2007–2007
- Chico Salmon 1964–1972
- Harry Salmon 1923–1935
- Roger Salmon 1912–1912
- Tim Salmon 1992–2006
- Angel Salome 2008–2008
- Jarrod Saltalamacchia 2007–2018
- Edward Salters 1925–1937
- Jack Saltzgaver 1932–1945
- Manuel Salvat 1925–1925
- Gus Salve 1908–1908
- Jack Salveson 1933–1945
- Manny Salvo 1939–1943
- Jeff Samardzija 2008–2020
- Joe Sambito 1976–1987
- Ed Samcoff 1951–1951
- Ron Samford 1954–1959
- Bryan Sammons 2024–2024
- Clint Sammons 2007–2009
- Bill Sampen 1990–1994
- Billy Sample 1978–1986
- Adrian Sampson 2016–2022
- Benj Sampson 1998–1999
- Chris Sampson 2006–2010
- Emanuel Sampson 1940–1946
- Keyvius Sampson 2015–2016
- Ormond Sampson 1932–1941
- Tommy Sampson 1940–1948
- Amado Samuel 1962–1964
- Juan Samuel 1983–1998
- Ike Samuels 1895–1895
- Joe Samuels 1930–1930
- Roger Samuels 1988–1989
- Pedro San 1926–1928
- Alex Sanabia 2010–2013
- Carlos Sanabria 2020–2020
- Brian Sanches 2006–2012
- Aaron Sanchez 2014–2022
- Adrian Sanchez 2017–2021
- Alejandro Sanchez 1982–1987
- Alex Sanchez 2001–2005
- Alex Sanchez 1989–1989
- Ali Sanchez 2020–2025
- Angel Sanchez 2006–2013
- Angel Sanchez 2017–2017
- Anibal Sanchez 2006–2022
- Carlos Sanchez 2014–2022
- Celerino Sanchez 1972–1973
- Cristopher Sanchez 2021–2025
- Duaner Sanchez 2002–2009
- Eduardo Sanchez 2011–2013
- Felix Sanchez 2003–2003
- Freddy Sanchez 2002–2011
- Gaby Sanchez 2008–2014
- Gary Sanchez 2015–2025
- Hector Sanchez 2011–2017
- Humberto Sanchez 2008–2008
- Israel Sanchez 1988–1990
- Jesus Sanchez 2020–2025
- Jesus Sanchez 1998–2004
- Jonathan Sanchez 2006–2013
- Luis Sanchez 1981–1985
- Miguel Sanchez 2021–2022
- Orlando Sanchez 1981–1984
- Raul Sanchez 1952–1960
- Rey Sanchez 1991–2005
- Ricardo Sanchez 2020–2020
- Romulo Sanchez 2007–2010
- Sixto Sanchez 2020–2024
- Tony Sanchez 2013–2017
- Heinie Sand 1923–1928
- Gus Sandberg 1923–1924
- Jared Sandberg 2001–2003
- Ryne Sandberg 1981–1997
- Anthony Sanders 1999–2001
- Ben Sanders 1888–1892
- Cam Sanders 2025–2025
- David Sanders 2003–2005
- Dee Sanders 1945–1945
- Deion Sanders 1989–2001
- John Sanders 1965–1965
- Ken Sanders 1964–1976
- Leo Sanders 1937–1942
- Phoenix Sanders 2022–2022
- Ray Sanders 1942–1949
- Reggie Sanders 1991–2007
- Reggie Sanders 1974–1974
- Roy Sanders 1918–1920
- Roy Sanders 1917–1918
- Scott Sanders 1993–1999
- War Sanders 1903–1904
- John Sanderson 1947–1947
- Scott Sanderson 1978–1996
- Nick Sandlin 2021–2025
- Mike Sandlock 1942–1953
- Danny Sandoval 2005–2006
- Freddy Sandoval 2008–2009
- Pablo Sandoval 2008–2021
- Patrick Sandoval 2019–2024
- Jayvien Sandridge 2025–2025
- Charlie Sands 1967–1975
- Cole Sands 2022–2025
- Donny Sands 2022–2022
- Jerry Sands 2011–2016
- Tommy Sandt 1975–1976
- Chance Sanford 1998–1999
- Fred Sanford 1943–1951
- Jack Sanford 1956–1967
- Jack Sanford 1940–1946
- Mo Sanford 1991–1995
- Manny Sanguillen 1967–1980
- Ed Sanicki 1949–1951
- Amauri Sanit 2011–2011
- Ben Sankey 1929–1931
- Reiver Sanmartin 2021–2025
- Miguel Sano 2015–2024
- Javier Sanoja 2024–2025
- Anastasio Santaella 1935–1936
- Andres Santana 1990–1990
- Carlos Santana 2010–2025
- Danny Santana 2014–2021
- Dennis Santana 2018–2025
- Domingo Santana 2014–2020
- Edgar Santana 2017–2021
- Ervin Santana 2005–2021
- Johan Santana 2000–2012
- Julio Santana 1997–2006
- Marino Santana 1998–1999
- Pedro Santana 2001–2001
- Rafael Santana 1983–1990
- Anthony Santander 2017–2025
- F. P. Santangelo 1995–2001
- Benito Santiago 1986–2005
- Carlos Santiago 1946–1946
- Hector Santiago 2011–2021
- Jose Santiago 1997–2005
- Jose Santiago 1963–1970
- José Santiago 1948–1956
- Ramon Santiago 2002–2014
- Tony Santillan 2021–2025
- Ron Santo 1960–1974
- Louis Santop 1910–1926
- Al Santorini 1968–1973
- Angel Santos 2001–2003
- Antonio Santos 2020–2021
- Chad Santos 2006–2006
- Francisco Santos 2003–2003
- Gregory Santos 2021–2025
- Luis Santos 2017–2018
- Omir Santos 2008–2013
- Sergio Santos 2010–2015
- Victor Santos 2001–2007
- Nelson Santovenia 1987–1993
- Edward Santry 1884–1884
- Dave Sappelt 2011–2013
- Luis Sardinas 2014–2018
- Bronson Sardinha 2007–2007
- Dane Sardinha 2003–2011
- Dennis Sarfate 2006–2009
- Joe Sargent 1921–1921
- Manny Sarmiento 1976–1983
- Bill Sarni 1951–1956
- Andy Sarvis 1939–1942
- Kazuhiro Sasaki 2000–2003
- Roki Sasaki 2025–2025
- Mackey Sasser 1987–1995
- Rob Sasser 1998–1998
- Josh Satin 2011–2014
- Tom Satriano 1961–1970
- Alf Satterfield 1907–1911
- Luis Saturria 2000–2001
- Tayler Saucedo 2021–2025
- Frank Saucier 1951–1951
- Kevin Saucier 1978–1982
- Ed Sauer 1943–1949
- Hank Sauer 1941–1959
- Matt Sauer 2024–2025
- Scott Sauerbeck 1999–2006
- sault01 1916–1916
- Augustus Saunders 1927–1932
- Bob Saunders 1926–1926
- Clifford Saunders 1924–1924
- Dennis Saunders 1970–1970
- Doug Saunders 1993–1993
- Joe Saunders 2005–2014
- Michael Saunders 2009–2017
- Rusty Saunders 1927–1927
- Tony Saunders 1997–1999
- Warwick Saupold 2016–2018
- Al Sauter 1890–1890
- Rich Sauveur 1986–2000
- Bob Savage 1942–1949
- Don Savage 1944–1945
- Jack Savage 1987–1990
- Jim Savage 1925–1925
- Jimmie Savage 1912–1915
- Junius Savage 1940–1940
- Ted Savage 1962–1971
- Bob Saverine 1959–1967
- Joe Savery 2011–2014
- Don Savidge 1929–1929
- Ralph Savidge 1908–1909
- Moe Savransky 1954–1954
- Hirokazu Sawamura 2021–2022
- Carl Sawatski 1948–1963
- Carl Sawyer 1915–1916
- Rick Sawyer 1974–1977
- Will Sawyer 1883–1883
- Dave Sax 1982–1987
- Ollie Sax 1928–1928
- Steve Sax 1981–1994
- Thomas Saxon 1942–1942
- Jimmy Say 1882–1887
- Lou Say 1873–1884
- Bill Sayles 1939–1943
- Alfred Saylor 1941–1945
- Phil Saylor 1891–1891
- Jay Sborz 2010–2010
- Josh Sborz 2019–2024
- Rob Scahill 2012–2018
- Jerry Scala 1948–1950
- Bobby Scales 2009–2010
- George Scales 1921–1946
- Junior Scales 1943–1943
- Johnny Scalzi 1931–1931
- Skeeter Scalzi 1939–1939
- Bob Scanlan 1991–2001
- Doc Scanlan 1903–1911
- Frank Scanlan 1909–1909
- Mort Scanlan 1890–1890
- Pat Scanlon 1974–1977
- Pat Scanlon 1884–1884
- Patricio Scantlebury 1944–1956
- Randy Scarbery 1979–1980
- Ray Scarborough 1942–1953
- Mac Scarce 1972–1978
- Russ Scarritt 1929–1932
- Les Scarsella 1935–1940
- Steve Scarsone 1992–1999
- Mac Sceroler 2021–2021
- Paul Schaal 1964–1974
- Al Schacht 1919–1921
- Sid Schacht 1950–1951
- Hal Schacker 1945–1945
- Germany Schaefer 1901–1918
- Jeff Schaefer 1989–1994
- Harry Schaeffer 1952–1952
- Jesse Schaeffer 1911–1911
- Mark Schaeffer 1972–1972
- Harry Schafer 1871–1878
- Jordan Schafer 2009–2015
- Logan Schafer 2011–2016
- Jimmie Schaffer 1961–1968
- Joe Schaffernoth 1959–1961
- Johnny Schaive 1958–1963
- Ray Schalk 1912–1929
- Roy Schalk 1932–1945
- Gene Schall 1995–1996
- Walter Schaller 1911–1913
- Art Schallock 1951–1955
- Bobby Schang 1914–1927
- Wally Schang 1913–1931
- Nolan Schanuel 2023–2025
- Charley Schanz 1944–1950
- John Schappert 1882–1882
- Bill Schardt 1911–1912
- Art Scharein 1932–1934
- George Scharein 1937–1940
- Nick Scharf 1882–1883
- Jeff Schattinger 1981–1981
- Dan Schatzeder 1977–1991
- Rube Schauer 1913–1917
- Scott Schebler 2015–2021
- Al Scheer 1913–1915
- Heinie Scheer 1922–1923
- Fritz Scheeren 1914–1915
- Owen Scheetz 1943–1943
- Aaron Scheffer 1999–1999
- Bob Scheffing 1941–1951
- Ted Scheffler 1888–1890
- Lefty Schegg 1912–1912
- Carl Scheib 1943–1954
- Frank Scheibeck 1887–1906
- Jack Scheible 1893–1894
- Rich Scheid 1992–1995
- Richie Scheinblum 1965–1974
- Danny Schell 1954–1955
- Jim Schelle 1939–1939
- Al Schellhase 1890–1891
- Fred Schemanske 1923–1923
- Mike Schemer 1945–1946
- Bill Schenck 1882–1885
- John Scheneberg 1913–1920
- Hank Schenz 1946–1951
- Joe Schepner 1919–1919
- Tanner Scheppers 2012–2017
- Bob Scherbarth 1950–1950
- Harry Scherer 1889–1889
- Fred Scherman 1969–1976
- Bill Scherrer 1982–1988
- Max Scherzer 2008–2025
- Dutch Schesler 1931–1931
- Lou Schettler 1910–1910
- Lou Schiappacasse 1902–1902
- Morrie Schick 1917–1917
- Nate Schierholtz 2007–2014
- Chuck Schilling 1961–1965
- Curt Schilling 1988–2007
- Red Schillings 1922–1922
- Ryan Schimpf 2016–2018
- Bill Schindler 1920–1920
- Calvin Schiraldi 1984–1991
- Dutch Schirick 1914–1914
- Larry Schlafly 1902–1914
- Admiral Schlei 1904–1911
- Daniel Schlereth 2009–2012
- Bill Schlesinger 1965–1965
- Travis Schlichting 2009–2010
- Dutch Schliebner 1923–1923
- Brian Schlitter 2010–2019
- Cam Schlittler 2025–2025
- Victor Schlitzer 1908–1914
- Gus Schlosser 2014–2014
- Jay Schlueter 1971–1971
- Norm Schlueter 1938–1944
- Brian Schmack 2003–2003
- Ray Schmandt 1915–1922
- George Schmees 1952–1952
- Al Schmelz 1967–1967
- Bob Schmidt 1958–1965
- Boss Schmidt 1906–1911
- Charles Schmidt 1909–1915
- Clarke Schmidt 2020–2025
- Curt Schmidt 1995–1995
- Dave Schmidt 1981–1981
- Dave Schmidt 1981–1992
- Freddy Schmidt 1944–1947
- Henry Schmidt 1903–1903
- Jason Schmidt 1995–2009
- Jeff Schmidt 1996–1996
- Konrad Schmidt 2010–2012
- Mike Schmidt 1972–1989
- Pete Schmidt 1913–1913
- Walter Schmidt 1916–1925
- Willard Schmidt 1952–1959
- Crazy Schmit 1890–1901
- Casey Schmitt 2023–2025
- Johnny Schmitz 1941–1956
- Steve Schmoll 2005–2005
- Hank Schmulbach 1943–1943
- Charlie Schmutz 1914–1915
- Dave Schneck 1972–1974
- Daniel Schneemann 2024–2025
- Frank Schneiberg 1910–1910
- Brian Schneider 2000–2012
- Dan Schneider 1963–1969
- Davis Schneider 2023–2025
- Jeff Schneider 1981–1981
- Pete Schneider 1914–1919
- Karl Schnell 1922–1923
- Gerry Schoen 1968–1968
- Red Schoendienst 1945–1963
- Jumbo Schoeneck 1884–1889
- Scott Schoeneweis 1999–2010
- Dick Schofield 1983–1996
- Dick Schofield 1953–1971
- Jesse Scholtens 2023–2025
- Otto Schomberg 1886–1888
- Mike Schooler 1988–1993
- Jerry Schoonmaker 1955–1957
- Jonathan Schoop 2013–2023
- Ed Schorr 1915–1915
- Gene Schott 1935–1939
- Pete Schourek 1991–2001
- Paul Schramka 1953–1953
- Ossee Schrecongost 1897–1908
- Barney Schreiber 1911–1911
- Hank Schreiber 1914–1926
- John Schreiber 2019–2025
- Paul Schreiber 1922–1945
- Ted Schreiber 1963–1963
- Steve Schrenk 1999–2000
- Pop Schriver 1886–1901
- Max Schrock 2020–2022
- Bob Schroder 1965–1968
- Chris Schroder 2006–2008
- Bill Schroeder 1983–1990
- Al Schroll 1958–1961
- Ken Schrom 1980–1987
- Rick Schu 1984–1996
- Heinie Schuble 1927–1936
- Ron Schueler 1972–1979
- Max Schuemann 2024–2025
- A. J. Schugel 2015–2017
- Dave Schuler 1979–1985
- Erik Schullstrom 1994–1995
- Wes Schulmerich 1931–1934
- Art Schult 1953–1960
- Frank Schulte 1904–1918
- Fred Schulte 1927–1937
- Ham Schulte 1940–1940
- Jack Schulte 1906–1906
- Johnny Schulte 1923–1932
- Len Schulte 1944–1946
- Barney Schultz 1955–1965
- Bo Schultz 2014–2016
- Bob Schultz 1951–1955
- Buddy Schultz 1975–1979
- Howie Schultz 1943–1948
- Jaime Schultz 2018–2019
- Joe Schultz 1939–1948
- Joe Schultz 1912–1925
- John Schultz 1891–1891
- Mike Schultz 1947–1947
- Mike Schultz 2007–2007
- Paxton Schultz 2025–2025
- Webb Schultz 1924–1924
- Al Schulz 1912–1916
- Jeff Schulz 1989–1991
- Walt Schulz 1920–1920
- Don Schulze 1983–1989
- John Schulze 1891–1891
- Hal Schumacher 1931–1946
- Skip Schumaker 2005–2015
- Hack Schumann 1906–1906
- Aaron Schunk 2024–2025
- Ferdie Schupp 1913–1922
- Wayne Schurr 1964–1964
- Bill Schuster 1937–1945
- Patrick Schuster 2016–2016
- Carl Schutz 1996–1996
- Mike Schwabe 1989–1990
- Don Schwall 1961–1967
- Ralph Schwamb 1948–1948
- Kyle Schwarber 2015–2025
- Bill Schwartz 1883–1884
- Bill Schwartz 1904–1904
- Randy Schwartz 1965–1966
- Jeff Schwarz 1993–1994
- Al Schweitzer 1908–1911
- Spencer Schwellenbach 2024–2025
- Rudy Schwenck 1909–1909
- Hal Schwenk 1913–1913
- Pi Schwert 1914–1915
- Michael Schwimer 2011–2012
- Art Schwind 1912–1912
- Frank Schwindel 2019–2022
- Chris Schwinden 2011–2012
- Jerry Schypinski 1955–1955
- Mike Scioscia 1980–1992
- Lou Scoffic 1936–1936
- Jim Scoggins 1913–1913
- Daryl Sconiers 1981–1985
- Herb Score 1955–1962
- Joe Scotland 1913–1914
- Bill Scott 1948–1948
- Bob Scott 1920–1927
- Bobby Scott 1938–1941
- Christian Scott 2024–2024
- Darryl Scott 1993–1993
- Death Valley Scott 1916–1916
- Dick Scott 1963–1964
- Dick Scott 1989–1989
- Dick Scott 1901–1901
- Donnie Scott 1983–1991
- Ed Scott 1900–1901
- Eugene Scott 1920–1920
- Everett Scott 1914–1926
- Gary Scott 1991–1992
- George Scott 1920–1920
- George Scott 1966–1979
- Jack Scott 1916–1929
- Jim Scott 1909–1917
- Joe Burt Scott 1945–1948
- Joe Scott 1927–1936
- Joe Scott 1948–1948
- John Scott 1914–1914
- John Scott 1974–1977
- Johnie Scott 1944–1948
- LeGrant Scott 1939–1939
- Lloyd Scott 1934–1934
- Luke Scott 2005–2013
- Marshall Scott 1945–1945
- Mickey Scott 1972–1977
- Mike Scott 1979–1991
- Milt Scott 1882–1886
- Pete Scott 1926–1928
- Robby Scott 2016–2019
- Rodney Scott 1975–1982
- Tanner Scott 2017–2025
- Tayler Scott 2019–2025
- Tim Scott 1991–1997
- Tony Scott 1973–1984
- Victor Scott 2024–2025
- scott01 1884–1884
- scott02 1938–1938
- Jim Scranton 1984–1985
- Evan Scribner 2011–2017
- Troy Scribner 2017–2018
- Chuck Scrivener 1975–1977
- Johnnie Scroggins 1947–1947
- Andre Scrubb 2020–2021
- Tony Scruggs 1991–1991
- Xavier Scruggs 2014–2016
- Scott Scudder 1989–1993
- Rod Scurry 1980–1988
- Marco Scutaro 2002–2014
- Scott Seabol 2001–2005
- Connor Seabold 2021–2025
- Corey Seager 2015–2025
- Kyle Seager 2011–2021
- Chandler Seagle 2023–2023
- Johnnie Seale 1964–1965
- Kim Seaman 1979–1980
- Rudy Seanez 1989–2008
- Ray Searage 1981–1990
- Steve Searcy 1988–1992
- JP Sears 2022–2025
- Ken Sears 1943–1946
- Todd Sears 2002–2003
- Tom Seaton 1912–1917
- Tom Seats 1940–1945
- Tom Seaver 1967–1986
- Bobby Seay 2001–2009
- Dick Seay 1926–1947
- Bob Sebra 1985–1990
- Jimmy Sebring 1902–1909
- Doc Sechrist 1899–1899
- Frank Secory 1940–1946
- Don Secrist 1969–1970
- Chris Seddon 2007–2012
- Duke Sedgwick 1921–1923
- Shawn Sedlacek 2002–2002
- Cody Sedlock 2022–2022
- Charlie See 1919–1921
- Larry See 1986–1988
- Bob Seeds 1930–1940
- Chris Seelbach 2000–2001
- Chuck Seelbach 1971–1974
- Pat Seerey 1943–1949
- Emmett Seery 1884–1892
- Kevin Sefcik 1995–2001
- Rob Segedin 2016–2017
- Herman Segelke 1982–1982
- Zack Segovia 2007–2009
- J. C. Segraves 1937–1937
- Sam Segraves 1942–1943
- Kal Segrist 1952–1955
- David Segui 1990–2004
- Diego Segui 1962–1977
- Fernando Seguignol 1998–2003
- Jean Segura 2012–2023
- Jose Segura 1988–1991
- Phil Seibel 2004–2004
- Kurt Seibert 1979–1979
- Socks Seibold 1915–1933
- Anthony Seigler 2025–2025
- Ricky Seilheimer 1980–1980
- Kevin Seitzer 1986–1997
- Kip Selbach 1894–1906
- Bill Selby 1996–2003
- Colin Selby 2023–2025
- Bee Selden 1910–1914
- William Selden 1891–1899
- Aaron Sele 1993–2007
- Todd Self 2005–2005
- George Selkirk 1934–1942
- Epp Sell 1922–1923
- Jeff Sellers 1985–1988
- Justin Sellers 2011–2014
- Rube Sellers 1910–1910
- selle01 1921–1921
- Frank Sellman 1871–1875
- Dave Sells 1972–1975
- Dick Selma 1965–1974
- Sam Selman 2019–2022
- Carey Selph 1929–1932
- Steve Selsky 2016–2017
- Mike Sember 1977–1978
- Carroll Sembera 1965–1970
- Marcus Semien 2013–2025
- Frank Seminara 1992–1994
- Andy Seminick 1943–1957
- Ray Semproch 1958–1961
- Sonny Senerchia 1952–1952
- Kodai Senga 2023–2025
- Hayden Senger 2025–2025
- Count Sensenderfer 1871–1874
- Paul Sentell 1906–1907
- Steve Senteney 1982–1982
- Antonio Senzatela 2017–2025
- Nick Senzel 2019–2024
- Jae Weong Seo 2002–2007
- Manny Seoane 1977–1978
- Andrew Sephus 1938–1938
- Ted Sepkowski 1942–1947
- Leyson Septimo 2012–2012
- Billy Serad 1884–1888
- Dan Serafini 1996–2007
- Bill Serena 1949–1954
- Paul Serna 1981–1982
- Alex Serrano 2008–2008
- Jimmy Serrano 2004–2004
- Wascar Serrano 2001–2001
- Bonnie Serrell 1941–1945
- Gary Serum 1977–1979
- Scott Servais 1991–2001
- Brian Serven 2022–2024
- Scott Service 1988–2004
- Walter Sessi 1941–1946
- Merle Settlemire 1928–1928
- John Sevcik 1965–1965
- Hank Severeid 1911–1926
- Anderson Severino 2022–2022
- Atahualpa Severino 2011–2011
- Luis Severino 2015–2025
- Pedro Severino 2015–2022
- Al Severinsen 1969–1972
- Rich Severson 1970–1971
- Paul Sewald 2017–2025
- Ed Seward 1885–1891
- Frank Seward 1943–1944
- George Seward 1875–1882
- Joe Sewell 1920–1933
- Luke Sewell 1921–1942
- Rip Sewell 1932–1949
- Tommy Sewell 1927–1927
- Elmer Sexauer 1948–1948
- Richie Sexson 1997–2008
- Chris Sexton 1999–2000
- Frank Sexton 1895–1895
- Jimmy Sexton 1977–1983
- Tom Sexton 1884–1884
- Socks Seybold 1899–1908
- Gordon Seyfried 1963–1964
- Bob Seymour 2025–2025
- Carson Seymour 2025–2025
- Cy Seymour 1896–1913
- Ian Seymour 2025–2025
- Jake Seymour 1882–1882
- Adam Shabala 2005–2005
- Brian Shackelford 2005–2006
- John Shackelford 1924–1930
- Kevin Shackelford 2017–2018
- Justin Shafer 2018–2020
- Orator Shafer 1874–1890
- Ralph Shafer 1914–1914
- Taylor Shafer 1884–1890
- Tillie Shafer 1909–1913
- Frank Shaffer 1884–1884
- John Shaffer 1886–1887
- Richie Shaffer 2015–2016
- shaff01 1875–1875
- Gus Shallix 1884–1885
- Jimmy Shamberger 1938–1940
- Art Shamsky 1965–1972
- Warren Shanabrook 1906–1906
- Greg Shanahan 1973–1974
- Wally Shaner 1923–1929
- Harvey Shank 1970–1970
- Howie Shanks 1912–1925
- John Shanks 1927–1927
- shank01 1945–1945
- Harry Shanley 1912–1912
- Jim Shanley 1876–1876
- Bill Shanner 1920–1920
- Dan Shannon 1889–1891
- Frank Shannon 1892–1896
- Joe Shannon 1915–1915
- Mike Shannon 1962–1970
- Owen Shannon 1903–1907
- Red Shannon 1915–1926
- Spike Shannon 1904–1908
- Wally Shannon 1959–1960
- shann01 1932–1932
- Billy Shantz 1954–1960
- Bobby Shantz 1949–1964
- Ralph Sharman 1917–1917
- Dick Sharon 1973–1975
- Bill Sharp 1973–1976
- Sterling Sharp 2020–2020
- Bud Sharpe 1905–1910
- Pepper Sharpe 1943–1948
- sharp01 1923–1923
- Mike Sharperson 1987–1995
- Josh Sharpless 2006–2007
- George Sharrott 1893–1894
- Jack Sharrott 1890–1893
- Shag Shaughnessy 1905–1908
- Joe Shaute 1922–1934
- Jon Shave 1993–1999
- Jeff Shaver 1988–1988
- Al Shaw 1901–1909
- Al Shaw 1907–1915
- Ben Shaw 1917–1918
- Bob Shaw 1957–1967
- Bryan Shaw 2011–2024
- Chris Shaw 2018–2019
- Don Shaw 1967–1972
- Dupee Shaw 1883–1888
- Herb Shaw 1942–1942
- Hunky Shaw 1908–1908
- Jeff Shaw 1990–2001
- Jim Shaw 1913–1921
- Matt Shaw 2025–2025
- Robert Shaw 1897–1897
- Sam Shaw 1888–1893
- Ted Shaw 1928–1930
- Travis Shaw 2015–2022
- shaw01 1920–1920
- Mike Shawaryn 2019–2019
- Bob Shawkey 1913–1927
- Danny Shay 1901–1907
- Marty Shay 1916–1924
- Gerry Shea 1905–1905
- John Shea 1928–1928
- Merv Shea 1927–1944
- Mike Shea 1887–1887
- Nap Shea 1902–1902
- Red Shea 1918–1922
- Spec Shea 1947–1955
- Steve Shea 1968–1969
- Danny Sheaffer 1987–1997
- Dan Sheahan 1884–1884
- Al Shealy 1928–1930
- Ryan Shealy 2005–2010
- Dave Shean 1906–1919
- Ray Shearer 1957–1957
- Tom Shearn 2007–2007
- John Shearon 1891–1896
- George Shears 1912–1912
- Jimmy Sheckard 1897–1913
- Emmet Sheehan 2023–2025
- Jack Sheehan 1920–1921
- Jim Sheehan 1936–1936
- Timothy Sheehan 1895–1896
- Tom Sheehan 1915–1926
- Tommy Sheehan 1900–1908
- Bud Sheely 1951–1953
- Earl Sheely 1921–1931
- Chuck Sheerin 1936–1936
- Andy Sheets 1996–2002
- Ben Sheets 2001–2012
- Gavin Sheets 2021–2025
- Larry Sheets 1984–1993
- Gary Sheffield 1988–2009
- Jordan Sheffield 2021–2022
- Justus Sheffield 2018–2022
- Hiawatha Shelby 1941–1941
- John Shelby 1981–1991
- Bob Sheldon 1974–1977
- Rollie Sheldon 1961–1966
- Scott Sheldon 1997–2001
- Steven Shell 2008–2009
- Frank Shellenback 1918–1919
- Jim Shellenback 1966–1977
- Hugh Shelley 1935–1935
- Ben Shelton 1993–1993
- Chris Shelton 2004–2009
- Jeff Shelton 1943–1946
- Skeeter Shelton 1915–1915
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- Jake Smolinski 2014–2018
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- Drew Smyly 2012–2024
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- Charlie Snell 1912–1912
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- John Snyder 1998–2000
- Josh Snyder 1872–1872
- Kyle Snyder 2003–2008
- Nicklaus Snyder 2021–2022
- Pop Snyder 1873–1891
- Russ Snyder 1959–1970
- Scott Sobkowiak 2001–2001
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- Miguel Socolovich 2012–2018
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- Eric Soderholm 1971–1980
- Steve Soderstrom 1996–1996
- Tyler Soderstrom 2023–2025
- Clint Sodowsky 1995–1999
- Ray Soff 1986–1987
- Rick Sofield 1979–1981
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- Nick Sogard 2024–2025
- Luis Sojo 1990–2003
- Tony Solaita 1968–1979
- Nick Solak 2019–2025
- Donovan Solano 2012–2025
- Jhonatan Solano 2012–2015
- Julio Solano 1983–1989
- Yangervis Solarte 2014–2019
- solde01 1932–1932
- Alay Soler 2006–2006
- Jorge Soler 2014–2025
- Ali Solis 2012–2014
- Marcelino Solis 1958–1958
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- Eddie Solomon 1973–1982
- Jared Solomon 2022–2022
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- Peter Solomon 2021–2023
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- Miguel Solís 1928–1940
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- Andy Sommers 1887–1890
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- Andy Sonnanstine 2007–2011
- Lary Sorensen 1977–1988
- Zach Sorensen 2003–2005
- Joakim Soria 2007–2021
- Alfonso Soriano 1999–2014
- George Soriano 2023–2025
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- Paul Sorrento 1989–1999
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- Elias Sosa 1972–1983
- Henry Sosa 2011–2011
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- Jose Sosa 1975–1976
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- Allen Sothoron 1914–1926
- Elliot Soto 2020–2020
- Geovany Soto 2005–2017
- Giovanni Soto 2015–2015
- Gregory Soto 2019–2025
- Juan Soto 2018–2025
- Livan Soto 2022–2024
- Mario Soto 1977–1988
- Neftali Soto 2013–2014
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- Herb Souell 1940–1948
- Bennett Sousa 2022–2025
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- Bill Southworth 1964–1964
- Billy Southworth 1913–1929
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- Steven Souza 2014–2022
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- John Sowders 1887–1890
- Len Sowders 1886–1886
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- Bob Spade 1907–1910
- Warren Spahn 1942–1965
- Al Spalding 1871–1878
- Dick Spalding 1927–1928
- Denard Span 2008–2018
- Cory Spangenberg 2014–2022
- Al Spangler 1959–1971
- Buster Spann 1932–1932
- Bill Spanswick 1964–1964
- Glenn Sparkman 2017–2020
- Jeff Sparks 1999–2000
- Joe Sparks 1937–1940
- Steve Sparks 1995–2004
- Steve Sparks 2000–2000
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- Bob Speake 1955–1959
- Tris Speaker 1907–1928
- Charlie Spearman 1919–1929
- Clyde Spearman 1932–1946
- Codie Spearman 1926–1926
- Fred Spearman 1936–1936
- Henry Spearman 1935–1945
- Willie Spearman 1923–1927
- Nate Spears 2011–2012
- Alex Speas 2023–2024
- Cliff Speck 1986–1986
- By Speece 1924–1930
- Horace Speed 1975–1979
- Floyd Speer 1943–1944
- Kid Speer 1909–1909
- Tim Spehr 1991–1999
- Chris Speier 1971–1989
- Gabe Speier 2019–2025
- Justin Speier 1998–2009
- Ryan Speier 2005–2009
- Levale Speigner 2007–2008
- Bob Spence 1969–1971
- Josh Spence 2011–2012
- Mitch Spence 2024–2025
- Stan Spence 1940–1949
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- Chet Spencer 1906–1906
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- George Spencer 1950–1960
- Glenn Spencer 1928–1933
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- Ed Spiezio 1964–1972
- Scott Spiezio 1996–2007
- Charlie Spikes 1972–1980
- Ryan Spilborghs 2005–2011
- Dan Spillner 1974–1985
- Harry Spilman 1978–1989
- Hal Spindel 1939–1946
- Scipio Spinks 1969–1973
- Shea Spitzbarth 2021–2021
- Junior Spivey 2001–2005
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- Andy Spognardi 1932–1932
- Al Spohrer 1928–1935
- Paul Spoljaric 1994–2000
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- Karl Spooner 1954–1955
- Tim Spooneybarger 2001–2003
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- Charlie Sprague 1887–1890
- Ed Sprague 1991–2001
- Ed Sprague 1968–1976
- Harry Spratt 1911–1912
- George Spriggs 1965–1970
- Jack Spring 1955–1965
- Brad Springer 1925–1926
- Dennis Springer 1995–2002
- Ed Springer 1889–1889
- George Springer 2014–2025
- Russ Springer 1992–2010
- Steve Springer 1990–1992
- Jeffrey Springs 2018–2025
- Joe Sprinz 1930–1933
- Brandon Sproat 2025–2025
- Charlie Sproull 1945–1945
- Bob Sprout 1961–1961
- Bobby Sprowl 1978–1981
- Joe Spruill 1927–1927
- Zeke Spruill 2013–2014
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- Jay Spurgeon 2000–2000
- Chris Spurling 2003–2007
- Ed Spurney 1891–1891
- Mike Squires 1975–1985
- Joe Stabell 1885–1885
- George Stablein 1980–1980
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- Heinie Stafford 1916–1916
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- John Stafford 1893–1893
- staffbo01 1890–1890
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- Jake Stahl 1903–1913
- Larry Stahl 1964–1973
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- Roy Staiger 1975–1979
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- Tracy Stallard 1960–1966
- Virgil Stallcup 1947–1953
- George Staller 1943–1943
- George Stallings 1890–1898
- Jacob Stallings 2016–2025
- Eric Stamets 2019–2019
- Craig Stammen 2009–2022
- Hulon Stamps 1924–1928
- Oscar Stanage 1906–1925
- Charley Stanceu 1941–1946
- Jerry Standaert 1925–1929
- Jason Standridge 2001–2007
- Pete Standridge 1911–1915
- Al Stanek 1963–1963
- Ryne Stanek 2017–2025
- Kevin Stanfield 1979–1979
- Jason Stanford 2003–2007
- Daniel Stange 2010–2013
- Lee Stange 1961–1970
- Don Stanhouse 1972–1982
- Pete Stanicek 1987–1988
- Steve Stanicek 1987–1989
- Rob Stanifer 1997–2000
- Joe Stanka 1959–1959
- Tom Stankard 1904–1904
- Andy Stankiewicz 1992–1998
- Eddie Stanky 1943–1953
- Bob Stanley 1977–1989
- Buck Stanley 1911–1911
- Cody Stanley 2015–2015
- Fred Stanley 1969–1982
- Jim Stanley 1914–1914
- Joe Stanley 1884–1884
- Joe Stanley 1897–1909
- Mickey Stanley 1964–1978
- Mike Stanley 1986–2000
- Neck Stanley 1928–1948
- Paul Stanley 1940–1940
- Craig Stansberry 2007–2009
- Jack Stansbury 1918–1918
- Buck Stanton 1931–1931
- Giancarlo Stanton 2010–2025
- Leroy Stanton 1970–1978
- Mike Stanton 1989–2007
- Mike Stanton 1975–1985
- Tom Stanton 1904–1904
- Dave Stapleton 1980–1986
- Dave Stapleton 1987–1988
- Willie Stargell 1962–1982
- Denny Stark 1999–2009
- Dolly Stark 1909–1912
- Matt Stark 1987–1990
- Con Starkel 1906–1906
- Jim Starks 1927–1946
- Otis Starks 1919–1935
- stark01 1937–1937
- Bubba Starling 2019–2020
- George Starnagle 1902–1902
- Charlie Starr 1905–1909
- Dick Starr 1947–1951
- Ray Starr 1932–1945
- William Starr 1935–1936
- Herm Starrette 1963–1965
- Joe Start 1871–1886
- Cody Stashak 2019–2022
- Brock Stassi 2017–2017
- Max Stassi 2013–2022
- Dave Staton 1993–1994
- Joe Staton 1972–1973
- Arnold Statz 1919–1928
- Rusty Staub 1963–1985
- Ed Stauffer 1923–1925
- Tim Stauffer 2005–2015
- Josh Staumont 2019–2024
- Nick Stavinoha 2008–2010
- Turkey Stearnes 1923–1940
- Bill Stearns 1871–1875
- Dan Stearns 1880–1889
- John Stearns 1974–1984
- William Stecher 1890–1890
- Gene Stechschulte 2000–2002
- Drew Steckenrider 2017–2022
- John Stedronsky 1879–1879
- Bill Steele 1910–1914
- Bob Steele 1916–1919
- Ed Steele 1942–1948
- Elmer Steele 1907–1911
- Justin Steele 2021–2025
- Farmer Steelman 1899–1902
- Jim Steels 1987–1989
- Bill Steen 1912–1915
- Milt Steengrafe 1924–1926
- Kennie Steenstra 1998–1998
- Spencer Steer 2022–2025
- Gene Steere 1894–1894
- Morrie Steevens 1962–1965
- Michael Stefanic 2022–2025
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- Dave Stegman 1978–1984
- Bill Stein 1972–1985
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- Henry Stein 1900–1900
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- Justin Stein 1938–1938
- Randy Stein 1978–1982
- William Stein 1890–1890
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- Gene Steinbrenner 1912–1912
- Bill Steinecke 1931–1931
- Ray Steineder 1923–1924
- Ben Steiner 1945–1947
- Red Steiner 1945–1945
- Harry Steinfeldt 1898–1911
- Rick Steirer 1982–1984
- Bill Stellbauer 1916–1916
- Bill Stellberger 1885–1885
- Rick Stelmaszek 1971–1974
- Fred Stem 1908–1909
- Jeff Stember 1980–1980
- Steve Stemle 2005–2006
- Bill Stemmyer 1885–1888
- Casey Stengel 1912–1925
- Dave Stenhouse 1962–1964
- Mike Stenhouse 1982–1986
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- Jake Stenzel 1890–1899
- Trevor Stephan 2021–2023
- Buzz Stephen 1968–1968
- Albert Stephens 1948–1948
- Ben Stephens 1892–1894
- Bryan Stephens 1947–1948
- Clarence Stephens 1886–1891
- Gene Stephens 1952–1964
- Jackson Stephens 2017–2024
- Jake Stephens 1921–1937
- Jim Stephens 1907–1912
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- Phil Stephenson 1989–1992
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- Riggs Stephenson 1921–1934
- Robert Stephenson 2016–2025
- Tyler Stephenson 2020–2025
- Walter Stephenson 1935–1937
- John Sterling 1890–1890
- Randy Sterling 1974–1974
- Adam Stern 2005–2010
- Justin Sterner 2024–2025
- Charles Sterrett 1912–1913
- Mitch Stetter 2007–2011
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- Chad Stevens 2025–2025
- Chuck Stevens 1941–1948
- Dave Stevens 1994–2000
- Ed Stevens 1945–1950
- Foots Stevens 1927–1929
- Frank Stevens 1923–1929
- Jeff Stevens 2009–2011
- Jim Stevens 1914–1914
- Lee Stevens 1990–2002
- R C Stevens 1958–1961
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- Andrew Stevenson 2017–2023
- Cal Stevenson 2022–2025
- Willie Stevenson 1940–1943
- Todd Steverson 1995–1996
- stewa02 1940–1940
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- Archie Stewart 1923–1923
- Bill Stewart 1955–1955
- Brock Stewart 2016–2025
- Bud Stewart 1941–1954
- Bunky Stewart 1952–1956
- Chris Stewart 2006–2018
- Christin Stewart 2018–2020
- DJ Stewart 2018–2024
- Dave Stewart 1978–1995
- Frank Stewart 1934–1934
- Frank Stewart 1927–1927
- Glen Stewart 1940–1944
- Ian Stewart 2007–2014
- Jimmy Stewart 1963–1973
- Joe Stewart 1904–1904
- Josh Stewart 2003–2004
- Kohl Stewart 2018–2021
- Lefty Stewart 1921–1935
- Leon Stewart 1936–1940
- Mack Stewart 1944–1945
- Manuel Stewart 1946–1946
- Mark Stewart 1913–1913
- Neb Stewart 1940–1940
- Ossie Stewart 1943–1943
- Riley Stewart 1946–1948
- Sal Stewart 2025–2025
- Sammy Stewart 1978–1987
- Scott Stewart 2001–2004
- Shannon Stewart 1995–2008
- Stuffy Stewart 1916–1929
- Tuffy Stewart 1913–1914
- Zach Stewart 2011–2012
- stewa01 1920–1924
- Phil Stidham 1994–1994
- Dave Stieb 1979–1998
- Fred Stiely 1929–1931
- Jonathan Stiever 2020–2021
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- Kurt Stillwell 1986–1996
- Ron Stillwell 1961–1962
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- Archie Stimmel 1900–1902
- Carl Stimson 1923–1923
- Lee Stine 1934–1938
- Kelly Stinnett 1994–2007
- Bob Stinson 1969–1980
- Frank Stinson 1932–1932
- Josh Stinson 2011–2014
- Gat Stires 1871–1871
- Tom Stirman 1909–1912
- Snuffy Stirnweiss 1943–1952
- Matt Stites 2014–2015
- Jack Stivetts 1889–1899
- Chuck Stobbs 1947–1961
- Milt Stock 1913–1926
- Robert Stock 2018–2025
- Wes Stock 1959–1967
- Ted Stockard 1927–1931
- Kevin Stocker 1993–2000
- Mel Stocker 2007–2007
- Phil Stockman 2006–2008
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- Len Stockwell 1879–1890
- Bob Stoddard 1981–1987
- Tim Stoddard 1975–1989
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- Art Stokes 1925–1925
- Brian Stokes 2006–2010
- Troy Stokes 2021–2021
- Arnie Stone 1923–1924
- Dean Stone 1953–1963
- Dick Stone 1945–1945
- Dwight Stone 1913–1914
- Ed Stone 1934–1946
- Gavin Stone 2023–2024
- Gene Stone 1969–1969
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- George Stone 1967–1975
- Jeff Stone 1983–1990
- John Stone 1928–1938
- Ricky Stone 2001–2007
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- Steve Stone 1971–1981
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- Bill Stoneman 1967–1974
- Lil Stoner 1922–1931
- Tobi Stoner 2009–2010
- Jim Stoops 1998–1998
- Drew Storen 2010–2017
- Mickey Storey 2012–2013
- Howie Storie 1931–1932
- Alan Storke 1906–1909
- Lin Storti 1930–1933
- Trevor Story 2016–2025
- Bryson Stott 2022–2025
- Mel Stottlemyre 1990–1990
- Mel Stottlemyre 1964–1974
- Todd Stottlemyre 1988–2002
- Tom Stouch 1898–1898
- Levi Stoudt 2023–2023
- Allyn Stout 1931–1943
- Eric Stout 2018–2022
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- Jesse Stovall 1903–1904
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- Harry Stovey 1880–1893
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- Chris Stowers 1999–1999
- Kyle Stowers 2022–2025
- Mike Strahler 1970–1973
- Matt Strahm 2016–2025
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- Dan Straily 2012–2019
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- Les Straker 1987–1988
- Bob Strampe 1972–1972
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- Larry Strands 1915–1915
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- Alan Strange 1934–1942
- Doug Strange 1989–1998
- Pat Strange 2002–2003
- Dee Strange-Gordon 2011–2022
- Stephen Strasburg 2010–2022
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- Chris Stratton 2016–2025
- Ed Stratton 1873–1873
- Felton Stratton 1923–1933
- Hunter Stratton 2023–2025
- Monty Stratton 1934–1938
- Scott Stratton 1888–1895
- Joe Straub 1880–1883
- Ryan Strausborger 2015–2015
- Joe Strauss 1884–1886
- Myles Straw 2018–2025
- Darryl Strawberry 1983–1999
- Gabby Street 1904–1931
- Huston Street 2005–2017
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- Oscar Streit 1899–1902
- Ed Strelecki 1928–1931
- Phil Stremmel 1909–1910
- Walt Streuli 1954–1956
- Charles Strick 1882–1882
- Cub Stricker 1882–1893
- Bill Strickland 1937–1937
- George Strickland 1950–1960
- Henry Strickland 1924–1924
- Hunter Strickland 2014–2025
- Jim Strickland 1971–1975
- Scott Strickland 1999–2010
- Elmer Stricklett 1904–1907
- Spencer Strider 2021–2025
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- John Strike 1886–1886
- Jake Striker 1959–1960
- Nick Strincevich 1940–1948
- Lou Stringer 1941–1950
- Ross Stripling 2016–2024
- Joe Stripp 1928–1938
- Mark Strittmatter 1998–1998
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- John Strohmayer 1970–1974
- Brent Strom 1972–1977
- Marcus Stroman 2014–2025
- Floyd Stromme 1939–1939
- Jim Stroner 1929–1929
- Jamal Strong 2003–2005
- Joe Strong 2000–2001
- Joe Strong 1922–1937
- Ted Strong 1936–1948
- Pedro Strop 2009–2021
- Sam Strothers 1908–1913
- Ed Stroud 1966–1971
- Ralph Stroud 1910–1916
- Steve Stroughter 1982–1982
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- Al Strueve 1884–1884
- Amos Strunk 1908–1924
- Clarence Struss 1934–1934
- Sterling Stryker 1924–1926
- Peter Strzelecki 2022–2024
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- Dick Stuart 1958–1969
- Johnny Stuart 1922–1925
- Luke Stuart 1921–1921
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- CJ Stubbs 2025–2025
- Drew Stubbs 2009–2017
- Franklin Stubbs 1984–1995
- Garrett Stubbs 2019–2025
- Moose Stubing 1967–1967
- Sy Studley 1872–1872
- George Stueland 1921–1925
- Paul Stuffel 1950–1953
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- Eric Stults 2006–2015
- George Stultz 1894–1894
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- Bill Stumpf 1912–1913
- Daniel Stumpf 2016–2019
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- Guy Sturdy 1927–1928
- Bobby Sturgeon 1940–1948
- Dean Sturgis 1914–1914
- Johnny Sturm 1941–1941
- Tanyon Sturtze 1995–2008
- Michael Stutes 2011–2013
- George Stutz 1926–1926
- Lena Styles 1919–1931
- Chris Stynes 1995–2004
- Neil Stynes 1890–1890
- Albert Suarez 2016–2025
- Andrew Suarez 2018–2023
- Eugenio Suarez 2014–2025
- Jose Suarez 2019–2025
- Ken Suarez 1966–1973
- Luis Suarez 1944–1944
- Ranger Suarez 2018–2025
- Robert Suarez 2022–2025
- William Sublette 1908–1910
- Dick Such 1970–1970
- Charley Suche 1938–1938
- Jim Suchecki 1950–1952
- Tony Suck 1883–1884
- Jesus Sucre 2013–2019
- Bill Sudakis 1968–1975
- Pete Suder 1941–1955
- Willie Sudhoff 1897–1906
- Wander Suero 2018–2025
- William Suero 1992–1993
- Tomoyuki Sugano 2025–2025
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- George Suggs 1908–1915
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- Clyde Sukeforth 1926–1945
- Ed Sukla 1964–1966
- Guy Sularz 1980–1983
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- Andy Sullivan 1904–1904
- Bill Sullivan 1890–1890
- Bill Sullivan 1878–1878
- Billy Sullivan 1931–1947
- Billy Sullivan 1899–1916
- Brett Sullivan 2023–2025
- Charlie Sullivan 1928–1931
- Chub Sullivan 1877–1880
- Cory Sullivan 2005–2010
- Dan Sullivan 1882–1886
- Denny Sullivan 1879–1880
- Denny Sullivan 1905–1909
- Fleury Sullivan 1884–1884
- Frank Sullivan 1953–1963
- Harry Sullivan 1909–1909
- Haywood Sullivan 1955–1963
- Jackie Sullivan 1944–1944
- Jim Sullivan 1891–1898
- Jim Sullivan 1921–1923
- Joe Sullivan 1893–1896
- Joe Sullivan 1935–1941
- John Sullivan 1905–1908
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- John Sullivan 1919–1919
- John Sullivan 1963–1968
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- Lefty Sullivan 1939–1939
- Marc Sullivan 1982–1987
- Marty Sullivan 1887–1891
- Mike Sullivan 1888–1888
- Mike Sullivan 1889–1899
- Pat Sullivan 1884–1884
- Russ Sullivan 1951–1953
- Scott Sullivan 1995–2004
- Sleeper Sullivan 1881–1884
- Suter Sullivan 1898–1899
- Ted Sullivan 1884–1884
- Tom Sullivan 1922–1922
- Tom Sullivan 1884–1889
- Tom Sullivan 1925–1925
- William Sullivan 1884–1884
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- Beau Sulser 2022–2022
- Cole Sulser 2019–2025
- Homer Summa 1920–1930
- Champ Summers 1974–1984
- Ed Summers 1908–1912
- Kid Summers 1893–1893
- Lonnie Summers 1938–1938
- Tack Summers 1923–1928
- Carl Sumner 1928–1928
- William Sumrall 1938–1940
- Art Sunday 1890–1890
- Billy Sunday 1883–1890
- Jim Sundberg 1974–1989
- Gordie Sundin 1956–1956
- Steve Sundra 1936–1946
- Tom Sunkel 1937–1944
- Pete Sunkett 1943–1945
- Jeff Suppan 1995–2012
- B. J. Surhoff 1987–2005
- Rich Surhoff 1985–1985
- Eric Surkamp 2011–2016
- Max Surkont 1949–1957
- Andrew Susac 2014–2020
- George Susce 1955–1959
- George Susce 1929–1944
- Steve Susdorf 2013–2013
- Pete Susko 1934–1934
- Butch Sutcliffe 1938–1938
- Elmer Sutcliffe 1884–1892
- Rick Sutcliffe 1976–1994
- Brent Suter 2016–2025
- Harry Suter 1909–1909
- Darrell Sutherland 1964–1968
- Dizzy Sutherland 1949–1949
- Gary Sutherland 1966–1978
- Leo Sutherland 1980–1981
- Suds Sutherland 1921–1921
- Glenn Sutko 1990–1991
- Bruce Sutter 1976–1988
- Jack Sutthoff 1898–1905
- Mule Suttles 1923–1944
- Don Sutton 1966–1988
- Drew Sutton 2009–2012
- Ezra Sutton 1871–1888
- Jack Sutton 1911–1911
- John Sutton 1977–1978
- Larry Sutton 1997–2004
- Leroy Sutton 1940–1945
- Jack Suwinski 2022–2025
- Ichiro Suzuki 2001–2019
- Kurt Suzuki 2007–2022
- Mac Suzuki 1996–2002
- Seiya Suzuki 2022–2025
- José Suárez 1916–1921
- Matt Svanson 2025–2025
- Dale Sveum 1986–1999
- Harry Swacina 1907–1915
- Bill Swaggerty 1983–1986
- Travis Swaggerty 2022–2022
- Cy Swaim 1897–1898
- Andy Swan 1884–1884
- Craig Swan 1973–1984
- Harry Swan 1914–1914
- Russ Swan 1989–1994
- swan01 1933–1933
- Nolan Swancy 1924–1924
- Marty Swandell 1872–1873
- Pinky Swander 1903–1904
- Pedro Swann 2000–2003
- Bill Swanson 1914–1914
- Dansby Swanson 2016–2025
- Erik Swanson 2019–2025
- Evar Swanson 1929–1934
- Karl Swanson 1928–1929
- Red Swanson 1955–1957
- Stan Swanson 1971–1971
- Bill Swarback 1887–1887
- Matt Swarmer 2022–2022
- Ed Swartwood 1881–1892
- Bud Swartz 1947–1947
- Monty Swartz 1920–1920
- Dave Swartzbaugh 1995–1997
- Park Swartzel 1889–1889
- Anthony Swarzak 2009–2021
- Charlie Sweasy 1871–1878
- George Sweatt 1922–1927
- Bill Sweeney 1907–1914
- Bill Sweeney 1882–1884
- Bill Sweeney 1928–1931
- Brian Sweeney 2003–2010
- Buck Sweeney 1914–1914
- Charlie Sweeney 1882–1887
- Dan Sweeney 1895–1895
- Darnell Sweeney 2015–2018
- Ed Sweeney 1908–1919
- Harry Sweeney 1944–1944
- Jerry Sweeney 1884–1884
- Mark Sweeney 1995–2008
- Mike Sweeney 1995–2010
- Pete Sweeney 1888–1890
- Rooney Sweeney 1883–1885
- Ryan Sweeney 2006–2014
- Trey Sweeney 2024–2025
- Devin Sweet 2023–2023
- Rick Sweet 1978–1983
- Les Sweetland 1927–1931
- sweigha01 1890–1890
- Augie Swentor 1922–1922
- Steve Swetonic 1929–1935
- Pop Swett 1890–1890
- Bill Swift 1932–1943
- Bill Swift 1985–1998
- Bob Swift 1940–1953
- Oad Swigart 1939–1940
- Murray Swiggett 1911–1911
- Ad Swigler 1917–1917
- Blake Swihart 2015–2019
- Greg Swindell 1986–2002
- Josh Swindell 1911–1913
- Charlie Swindells 1904–1904
- R. J. Swindle 2008–2009
- Paul Swingle 1993–1993
- Nick Swisher 2004–2015
- Steve Swisher 1974–1982
- Jon Switzer 2003–2009
- Ron Swoboda 1965–1973
- Len Swormstedt 1901–1906
- Doug Sydnor 1943–1944
- Bob Sykes 1977–1981
- Doc Sykes 1914–1924
- Melvin Sykes 1926–1926
- Lou Sylvester 1884–1887
- Noah Syndergaard 2015–2023
- Thomas Szapucki 2021–2022
- Matt Szczur 2014–2018
- Joe Szekely 1953–1953
- Ken Szotkiewicz 1970–1970
- Jason Szuminski 2004–2004
- Gonzalo Sánchez 1909–1909
- Raúl Sánchez 1948–1948
- Andy Van Slyke 1983–1995
- Scott Van Slyke 2012–2017
- Luis de los Santos 1988–1991
- Luis de los Santos 2002–2002
- Ramon de los Santos 1974–1974